Clinical transplantation
Risk of Donor-Derived Infections From Organ Donors Colonized or Infected With Multidrug-Resistant Gram-Negative Bacteria: A Systematic Review and Meta-Analysis
By Paraskevas T, Chatzigrigoriadis C, Kostakis ID and 8 others.
Abstract
Background
The presence of multidrug-resistant Gram-negative (MDR-GN) organisms in solid organ transplantation (SOT) donors raises concerns regarding transplant safety.
Methods
We searched PubMed and Scopus (2010-2025) for observational studies reporting donor-derived infections (DDI) among SOT recipients from donors with MDR-GN colonization or infection. A single-arm meta-analysis was performed. Subgroup analyses examined donor risk categories (high-risk, low-risk), organ types, pathogen groups, and donor culture sites. 90-day mortality was estimated for recipients at risk of donor-to-recipient transmission based on presence of MDR-GN DDI.
