Journal of Infection and Public Health
Does macrolide resistance play a role in the clinical outcome of patients with
By Marek Stefan, Renata Sindlerova, Barbora Dratvova and 5 others.
Abstract
Background
A marked increase in Mycoplasma pneumoniae infections was observed across Europe in 2023, while data on resistance to macrolides, the recommended first-line therapy, remained limited. This study assessed the prevalence of macrolide-resistant M. pneumoniae (MRMP) and its impact on clinical outcomes.
Methods
Patients diagnosed with M. pneumoniae infection by multiplex PCR between January 2024 and January 2025 were included. Macrolide-resistance mutations were retrospectively identified by PCR and Sanger sequencing of domain V of the 23S rRNA gene. Clinical characteristics, treatment without results on the macrolide-resistant genotype, and outcomes were analysed.
