Topical Garcinia Mangostana Pericarp Extract Attenuates TPA-Induced Cutaneous Inflammation and Oxidative Stress in Mice: Preclinical Implications for Tumor Promotion-Related Inflammatory Mechanisms

Purpose

Persistent cutaneous inflammation and oxidative stress drive the promotion stage of skin carcinogenesis. Most evidence for Garcinia mangostana pericarp comes from purified α-mangostin tested in vitro or given systemically. We evaluated whether a standardized crude G. mangostana pericarp extract (GMPE) applied topically produces concentration-related anti-inflammatory and antioxidant effects in acute 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice.