Breast cancer
Cytoplasmic Basigin Localization is Associated with EMT, Tumor Budding, and Adverse Prognosis in Breast Cancer
By Xu X, Zhang Y, Fang H and 3 others.
Abstract
Purpose
To investigate the clinicopathological significance of Basigin subcellular localization in breast invasive ductal carcinoma, with particular emphasis on its association with epithelial-mesenchymal transition (EMT), tumor budding, and patient prognosis.
Methods
A total of 206 cases of primary breast invasive ductal carcinoma were retrospectively collected from Zhengzhou People's Hospital between January 2014 and January 2024. Immunohistochemistry was performed to evaluate the expression and subcellular localization of Basigin, E-cadherin, and Vimentin. Tumor budding was assessed according to the International Tumor Budding Consensus Conference (ITBCC) criteria. Associations between marker expression, clinicopathological parameters, and disease-free survival (DFS) were analyzed. A prognostic nomogram was subsequently constructed based on independent prognostic factors identified by multivariate Cox regression analysis.