Frontiers in immunology
Integrated single-cell and bulk tissue analyses reveal distinct macrophage subtypes and a candidate prognostic signature in colorectal cancer: implications for tumor immune characterization
By Chen H, Li Z, Lin Z and 5 others.
Abstract
Introduction
Colorectal cancer (CRC) represents a major global health burden, marked by high morbidity and mortality rates that place a considerable strain on healthcare systems.
Methods
This study leveraged integrated bioinformatic analyses, single-cell RNA sequencing, and clinical sample validation to investigate the role of macrophage-related genes (MRGs) in CRC, with the goal of deepening our understanding of the complex interplay within the tumor microenvironment.