Frontiers in immunology
Systematic evaluation of MAIT and iNKT abundance as checkpoint blockade biomarkers
By Li Y, Chen L, Shan S and 3 others.
Abstract
Introduction
MAIT and iNKT cells are unconventional T cell lineages that bridge innate and adaptive immunity and have been implicated in antitumor immune responses and immunotherapy outcomes. However, evidence to date has largely derived from individual studies of selected cancer types or specialized immune profiling cohorts. Whether MAIT and iNKT abundance provides reproducible clinical information across large, multi-cancer immune checkpoint blockade (ICB) cohorts remains insufficiently evaluated.