Genome medicine
Uncovering pan-cancer signatures of chemoresistance
By Inayatullah M, Demirdizen E, Keepers Z and 10 others.
Abstract
Background
Chemotherapy resistance remains a formidable challenge in cancer treatment, driving high mortality rates worldwide. Despite significant advancements, it remains unclear whether conserved molecular programs underpin therapy resistance across cancer types.
Methods
Here, we integrate single-cell RNA sequencing, spatial transcriptomics, regulatory network modeling, transcription factor binding data, and pharmacologic perturbation across multiple cancer types to define a conserved, proliferative chemoresistant tumor state.