Hollow-degree-tuned Prussian blue-mesoporous silica nanoplatforms for chemo-photothermal cancer therapy with preliminary microfluidic perfusion evaluation

Background

Balancing photothermal performance and drug-delivery capacity remains a key challenge in the structural design of multifunctional nanomedicines. Hollowing can increase internal space for drug accommodation but may simultaneously reduce the amount of NIR-absorbing Prussian blue (PB), creating an inherent trade-off between drug-delivery capacity and photothermal performance.