ImmunoTargets and therapy
A Single-Cell-Derived CD8+ T-Cell State Plasticity Score for Prognostic Stratification and Characterization of Immune Responsiveness in Hepatocellular Carcinoma
By Xing L, He D, Li DM and 11 others.
Abstract
Background
T cells play a central role in antitumor immunity. Emerging evidence indicates that T-cell plasticity and differentiation states are associated with clinical outcomes and responses to cancer immunotherapy. CD8⁺ T cells that retain differentiation potential are thought to sustain effective antitumor immunity. However, robust quantitative metrics for assessing tumor-infiltrating CD8+ T-cell state plasticity and defining its clinical significance in hepatocellular carcinoma remain lacking.