Radiotherapy versus observation following surgical resection of WHO grade 2 atypical meningioma (ROAM/EORTC-1308): an international, multicentre, open-label, phase 3, randomised controlled trial

WHO grade 2 atypical meningioma is a primary brain tumour with a high risk of recurrence even after complete surgical resection. The role of adjuvant radiotherapy remains uncertain. We aimed to assess whether adjuvant radiotherapy reduces recurrence compared with observation in patients with a newly diagnosed atypical meningioma who have undergone complete surgical resection.