Consensus recommendations for the management of locally advanced rectal cancer

Background

Locally advanced rectal cancer (LARC) considerably impairs quality of life (QoL) and compromises prognosis. Immunotherapy induces complete responses in most patients with mismatch repair deficient/microsatellite instability-high (dMMR/MSI-h) LARC, enabling organ preservation; however, challenges include access and inconsistent guideline recommendations. This Delphi study aimed to understand the unmet needs of patients with dMMR/MSI-h LARC and seek recommendations for appropriate diagnosis and management.