Immunity & inflammation
Disinhibiting dendritic cell-natural killer cell cooperation against metastasis
By Kepp O and Kroemer G.
Abstract
Metastatic tumors evade not only adaptive but also innate immune control. In a recent paper published in China Science Life Sciences, Jin and colleagues identify EID1 as a transcriptional and functional brake shared by dendritic cells (DCs) and natural killer (NK) cells. Genetic or nanoparticle-mediated EID1 inhibition strengthens DC-NK apposition, augments FPR1-dependent type I and II interferon responses through a mechanism involving FPR1 and potentially NK cell-derived ANXA1, and suppresses experimental metastatic colonization/outgrowth. The work connects a transcriptional-corepressor to innate immunosurveillance and suggests that the previously described ANXA1-FPR1 danger-sensing module may operate not only between dying cancer cells and DCs in primary sites, but also among NK cells and DCs at metastatic lesions.
Keywords
- Annexin A1
- Cancer immunosurveillance
- Dendritic cells
- Formyl peptide receptor 1
- Natural killer cells
Source
Published in Immunity & inflammation. The abstract is shown as published and remains the work of its authors; read the full article at the source.
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