Diagnostic Agreement between Manual Liquid-Based Cytology and Histopathology among HIV-Positive Women at Machakos Level 5 Hospital, Kenya

Aims

This study assessed the diagnostic agreement between manual liquid-based cervical cytology (MLBC) and histopathology among HIV-positive women attending Machakos Level 5 Hospital, Kenya. Study Design: A prospective comparative cross-sectional study. Place and Duration of Study: The study was conducted at the Comprehensive Care Centre, Machakos Level 5 Hospital, Machakos County, Kenya, between July and December 2020. Methodology: The study included 400 HIV-positive women attending the Comprehensive Care Centre. Cervical specimens were collected and processed using the manual liquid-based cytology technique. Cytological examination was performed by the principal investigator, while all abnormal smears were reviewed by a pathologist. Participants with cytological findings of high-grade squamous intraepithelial lesions or worse were referred for biopsy and histopathological examination. Cohen's kappa statistic was used to assess the level of agreement between manual liquid-based cervical cytology and histopathological findings.