Serum p27, p53, Lactate Dehydrogenase and Alkaline Phosphatase as Candidate Biomarkers in Breast Cancer in Port Harcourt, Nigeria

Background

Breast cancer remains a major cause of morbidity and mortality among women, with a substantial burden in resource-limited settings where access to advanced diagnostic facilities may be constrained. Although p27 and p53 are important tumour suppressor proteins and lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) are routinely measurable biochemical parameters, evidence regarding their combined circulating profiles in breast cancer remains limited. Evaluating these markers may help clarify their potential value as accessible adjuncts in the assessment of breast cancer patients.