Oxaliplatin and 5-Fluorouracil induce p53-p21-pRb-associated cell cycle arrest and a transient senescence-like phenotype in patient-derived low-grade serous ovarian cancer cells

Objectives

Low-grade serous ovarian cancer (LGSOC) is characterized by frequent TP53 wild-type status and limited responsiveness to conventional chemotherapy. This study investigated the cytotoxic effects of oxaliplatin (OXP) combined with 5-fluorouracil (5-FU) on patient-derived LGSOC cells.