Loading your page…
Dermatology Practical & Conceptual
By Pelin Ertop Doğan, Aybüke Nazlı Aydemir Geren, Emel Hazinedar and 3 others.
Kaposi sarcoma (KS) is an angioproliferative neoplasm driven by HHV-8 infection that exhibits variable clinical morphology across stages. Dermoscopy offers a noninvasive tool to capture the evolving structural changes in these lesions.
Ward brings these articles into the same app as your cards and questions. One free account for Ward, Suture, Osler and Prognia.
This study aimed to characterize dermoscopic patterns of KS according to clinical stage and to correlate these findings with histopathological features.
A retrospective analysis was conducted on 254 dermoscopically-documented KS lesions from 32 patients diagnosed between 2020 and 2024. Dermoscopic images were evaluated independently by two observers following the International Dermoscopy Society terminology. Statistical comparisons across patch, plaque, and nodular stages were performed using chi-square tests with Bonferroni correction.
Surface scale (75.2%) was the most common dermoscopic feature and increased significantly with advancing clinical stage (P=0.022). Polychromatic color change, collarette sign, ulceration, fiber sign, and blood spots were predominantly observed in plaque and nodular stages (P<0.001 for all). In contrast, pigment-related structures, particularly brown reticular lines and brown structureless areas (P<0.001), and four-dot clods (P=0.018) were significantly more frequent in patch lesions. Histopathologically, polychromatic color change corresponded to slit-like vascular spaces, erythrocyte extravasation, and hyaline globules, whereas pigment-related structures were associated with basal epidermal melanin and dermal hemosiderin deposition.
Dermoscopic features of KS vary significantly with clinical stage and parallel histopathological progression. Recognition of these stage-specific patterns may enhance the non-invasive assessment of KS and aid clinical differentiation from other vascular and pigmented tumors.
Published in Dermatology Practical & Conceptual. The abstract is shown as published and remains the work of its authors; read the full article at the source.
Prognia lists this article for reference and education. It is not medical advice. Always read the original and follow current guidelines and local protocols before acting on it.
