Zenodo
Tumor and exercising muscle — the same metabolic pathways with opposite outcomes: a narrative review
By Evgheni Grusac, Dionisie Cebotari, Daniel Cristea and 3 others.
Abstract
KEY POINTS OF THE ARTICLE Question / Importance. Existing reviews catalogue the mediators of exercise. This review starts from the metabolic similarity between tumor and contracting muscle and identifies demand coupling and signal termination as what separates them. The research hypothesis Contracting muscle and malignant tissue run the same core metabolic program. What differs is control: in muscle it terminates with contractile demand; in the tumor it is oncogene-driven and non-terminating. Physical activity is proposed to re-impose a self-terminating pattern on it.
Keywords
- Exercise and Physiological Responses
- Narrative review
- Metabolic pathway
- Skeletal muscle
- Muscle damage
- Narrative
- Metabolic syndrome
- Muscle tissue
- Review article
- Open access
Source
Published in Zenodo (CERN European Organization for Nuclear Research). The abstract is shown as published and remains the work of its authors; read the full article at the source.
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