Vaccines
Efficacy and Safety of Live Attenuated COVID-19 Vaccine Candidate Based on Omicron-like Temperature-Sensitive Mutant in Preclinical Study
By Е. Б. Файзулоев, Anastasiia V. Gracheva, E. R. Korchevaya and 13 others.
Abstract
Background/Objectives: Although the COVID-19 pandemic has ended, emerging SARS-CoV-2 variants remain a future threat. This study evaluated the safety and efficacy of an intranasal live attenuated vaccine (LAV) prototype based on a temperature-sensitive (ts) Omicron-like SARS-CoV-2 mutant in a Syrian hamster COVID-19 model.
