Pharmaceutics
All-Trans Retinoic Acid Nanocrystals for Enhanced Anticancer Activity Against Neuroblastoma Cancer Stem Cells
By Divya Ajmeera and Rajanna Ajumeera.
Abstract
Background/Objectives: Neuroblastoma is a high-risk pediatric malignancy in which cancer stem cells (CSCs) contribute to treatment resistance and disease recurrence. All-trans retinoic acid (ATRA) has established differentiation-inducing activity in neuroblastoma but is constrained by poor aqueous solubility and formulation challenges.