Inflammation Journal
Hypoxia and Serum Factor Modulate B7-H3 Expression in Prostate Cancer Cells
By Quynhchi Pham, Uyory Choe, Liangli Lucy Yu and 2 others.
Abstract
Background
Data on the expression and regulation of immune checkpoint inhibitors in prostate tissue and cells remain limited. This study aims to characterize the expression and regulatory mechanisms of B7-H3 (CD276) in prostate tissues and cell models.
Methods
In silico analyses were performed to evaluate the expression of B7-H3 and other checkpoint inhibitors in prostate tissues and cell lines. In vitro experiments assessed the impact of tumor microenvironmental factors on B7-H3 expression.