Diagnostics
The Pretherapy Endothelial Activation and Stress Index (EASIX) in Patients with Newly Diagnosed Acute Myeloid Leukemia: A Pilot Study
By Øystein Bruserud, Guido Smits, Silje Johanssen and 3 others.
Abstract
Background/Objectives: The endothelial activation and stress index (EASIX; serum creatinine times lactate dehydrogenase/peripheral blood platelet count) seems to reflect endothelial cell activation/dysfunction. Furthermore, endothelial cells support acute myeloid leukemia (AML) cell proliferation and survival, and high bone marrow microvascular density is associated with adverse prognosis in human AML.