Cancers
Enrichment-Free Rare Cell Profiling in Pediatric Osteosarcoma Reveals a Circulating Cell Population Associated with Relapse-Free Survival
By Stephanie N. Shishido, Siddhant Chaudhary, Ian Ward and 7 others.
Abstract
Background
Outcomes for patients with osteosarcoma (OS) presenting with metastases at diagnosis or relapsed remain poor with five-year survival rate of only 20–30%. Risk stratification at diagnosis remains limited, and no validated prognostic liquid biopsy analyte currently exists for this disease. OS lacks the recurring mutational hotspots and epithelial surface markers that underpin liquid biopsy strategies developed for carcinomas, necessitating fundamentally different approaches to circulating biomarker detection.