Cancers
A ZIP-Active Tumor Cell State Defines an NRF2-Associated Ferroptosis-Resistant and Immune-Cold Transcriptional Program in Head and Neck Squamous Cell Carcinoma
By Hideyuki Takahashi, Miho Uchida, Kaoru Takahashi and 4 others.
Abstract
Background/Objectives: Zinc homeostasis has emerged as an important regulator of cancer biology, yet the biological and clinical significance of zinc transporter-associated transcriptional programs in head and neck squamous cell carcinoma (HNSCC) remains poorly understood. This study aimed to identify zinc transporter-associated epithelial tumor cell states and evaluate their molecular and clinical significance.