Patient Preference and Adherence
Beyond Survival: Psychological Burden Impairs Medication Adherence in Chinese Patients with Chronic Myeloid Leukemia on TKI Therapy
By Fang Cheng, Zheng Cui, Qiang Li and 2 others.
Abstract
Background
Increasing research has linked mental health to reduced adherence in chronic diseases, yet this interplay remains insufficiently explored in chronic myeloid leukemia (CML).
Methods
We conducted a cross-sectional online survey to analyze the critical role of non-treatment factors among Chinese CML patients receiving tyrosine kinase inhibitor (TKI) therapy. Anxiety and depression were assessed with the GAD-7/PHQ-9, quality of life (QoL) with the SF-12. Medication adherence was assessed using the Medication Possession Ratio (MPR), calculated as the percentage of actual medication possession days relative to the theoretical medication possession days. Binary logistic regression was used to identify factors associated with psychological burden and adherence.