Spatial profiling of NUT carcinoma reveals an immunosuppressive myeloid-dominant microenvironment

Abstract Background: NUT carcinoma (NC) is an extremely rare and fatal fusion-driven malignancy, that can arise anywhere in the body. Because of its rarity, NC remains poorly understood and treatment relies on chemotherapy and radiotherapy regimens with limited response. Here, we aimed to generate the first comprehensive spatial single-cell profiling of NC to characterize the disease’s tumor immune microenvironment and uncover clinically relevant features.