Diagnostic and Prognostic Gene Signatures Linking Endoplasmic Reticulum Stress and Metabolic Reprogramming in Colon Cancer

Abstract Objective: Globally, Colon Cancer ranks among the leading cancers in incidence and mortality, and existing diagnostic and therapeutic options have considerable limitations, highlighting the need for novel biomarkers and therapeutic targets. This study aimed to integrate multi-cohort bulk and single-cell transcriptomic data to identify genes jointly associated with endoplasmic reticulum stress (ERS) and metabolic reprogramming in colon cancer, develop diagnostic and prognostic models, and characterize their immune and cell-type-specific contexts.