A Rare Case of Breast Cancer with Nasopharyngeal Metastasis: A Case Report and Literature Review

Abstract Although nasopharyngeal metastatic tumors are rare, breast cancer metastasis is uncommon. This report describes a 43-year-old female who developed a nasopharyngeal metastatic lesion after several cycles of breast cancer treatment. She was diagnosed with left breast infiltrating ductal carcinoma (pT2N0M0, Stage II) eight years ago. However, the patient did not undergo standard postoperative adjuvant therapy. She also developed axillary lymph node metastasis during the course of the illness. Although she underwent several systemic treatment cycles, imaging revealed aberrant nasopharyngeal hypertrophy. Endoscopy revealed a single elevated mass within the eustachian tube of the right pharyngeal recess. A pathological biopsy confirmed the diagnosis of breast cancer metastasis. Partial lesion response was achieved on MRIs after administering local intensity-modulated radiotherapy (IMRT, 66 Gy in 33 fractions). The present case underscores the need to be vigilant for atypical metastases during oncological follow-up, as well as the effectiveness of multidisciplinary cooperation in diagnosing and treating such tumors.