Feasibility of achieving a tumor- and drug-free state through conversion therapy followed by curative hepatectomy for patients with initially unresectable hepatocellular carcinoma (GUIDANCE009)

Background

Whether initially unresectable hepatocellular carcinoma (HCC) patients who receive curative resection after conversion therapy can maintain long-term tumor-free survival in a drug-free state after postoperative drug withdrawal is unclear. This study aimed to compare the effectiveness of adjuvant PD-1 inhibitors versus a drug-free state in these patients.