FDA
Phenylephrine Hydrochloride
The FDA lists this product in 60 strengths and forms.
Indications
Phenylephrine Hydrochloride Injection 10 mg per mL is indicated for increasing blood pressure in adults with clinically important hypotension resulting primarily from vasodilation in the settings of anesthesia and septic shock. Phenylephrine Hydrochloride Injection 10 mg per mL is alpha-1 adrenergic receptor agonist indicated for increasing blood pressure in adults with clinically important hypotension resulting primarily from vasodilation in the settings of anesthesia and septic shock.
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Contraindications
The use of phenylephrine hydrochloride injection 10 mg per mL is contraindicated in patients with: Hypersensitivity to the products or any of their components Hypersensitivity to the products or any of their components ( 4 )
Warnings and precautions
Severe bradycardia and decreased cardiac output : ( 5.2 ) Extravasation : during intravenous administration may cause necrosis or sloughing of tissue ( 5.4 ) Concomitant use with oxytocic drugs : pressor effect of sympathomimetic pressor amines is potentiated ( 5.5 ) Allergic-type reactions with phenylephrine hydrochloride injection 10 mg per mL : Sulfite ( 5.6 )
5.1Exacerbation of Angina, Heart Failure, or Pulmonary Arterial Hypertension Because
of its pressor effects, phenylephrine hydrochloride can precipitate angina in patients with severe arteriosclerosis or history of angina, exacerbate underlying heart failure, and increase pulmonary arterial pressure.
5.2Bradycardia
Phenylephrine hydrochloride injection 10 mg per mL can cause severe bradycardia and decreased cardiac output.