FDA
Phenylephrine Hydrochloride
The FDA lists this product in 60 strengths and forms.
Indications
Phenylephrine Hydrochloride Injection 10 mg/mL is indicated for increasing blood pressure in adults with clinically important hypotension resulting primarily from vasodilation in the settings of anesthesia and septic shock. Phenylephrine Hydrochloride Injection 10 mg/mL is alpha-1 adrenergic receptor agonist indicated for increasing blood pressure in adults with clinically important hypotension resulting primarily from vasodilation in the settings of anesthesia and septic shock.
Contraindications
The use of Phenylephrine Hydrochloride Injection 10 mg/mL is contraindicated in patients with: Hypersensitivity to the product or any of its components Hypersensitivity to the products or any of its components ( 4 )
Warnings and precautions
Severe bradycardia and decreased cardiac output : ( 5.2 ) Extravasation : during intravenous administration may cause necrosis or sloughing of tissue ( 5.4 ) Concomitant use with oxytocic drugs : pressor effect of sympathomimetic pressor amines is potentiated ( 5.5 )
5.1Exacerbation of Angina, Heart Failure, or Pulmonary Arterial Hypertension Because
of its pressor effects, phenylephrine hydrochloride can precipitate angina in patients with severe arteriosclerosis or history of angina, exacerbate underlying heart failure, and increase pulmonary arterial pressure.
5.2Bradycardia Phenylephrine Hydrochloride Injection
10 mg/mL can cause severe bradycardia and decreased cardiac output.
5.3Risk in Patients with Autonomic Dysfunction
The pressor response to adrenergic drugs, including phenylephrine, can be increased in patients with autonomic dysfunction, as may occur with spinal cord injuries.