NCCN Guidelines® Insights: Hepatocellular Carcinoma, Version 2.2026

Hepatocellular carcinoma (HCC) is the most common primary cancer of the liver. The NCCN Guidelines for HCC provide recommendations for the comprehensive care of patients with HCC, including screening, evaluation, treatment, and surveillance. The multidisciplinary panel of experts meets at least once a year to discuss updates to the NCCN Guidelines based on new and emerging data. These Guidelines Insights focus on some of the recent updates.