Medical Forum Monthly
The Role of TP53 Genetic Mutation in Breast Cancer Pathogenesis
By Soura Alaa Hussein, Ahmed Mudher Al-Khaykanee and Tiba A.H. Al-Rubaye.
Abstract
Objective
To review the role of TP53 genetic mutations in breast cancer Study Design: Case-control studyPlace and Duration of Study: This study was conducted at the Marjan Teaching Hospital in Babylon, from 1st December 2023 to 30th June 2025.
Methods
This case-control was conducted at Marjan Teaching Hospital in Babylon and 200 subject were enrolled, 100 patients with breast cancer and 100 healthy undivided were recruited. Subjects were selected at after theextraction of DNA the genotype of rs17878362 C/T and rs1042522 G/C was done using TaqMan-based Real-time PCR technique.