TMEM164 mRNA in Adult Glioblastoma: Multicohort Overexpression and RIPK1 Co-Expression Without Prognostic Replication

Background/Objectives: Experimental work has implicated TMEM164 in glioblastoma radioresistance through post-translational inhibition of FASN and suppression of radiation-induced necroptosis, supported clinically by a dichotomised single-database survival analysis. We tested whether the previously reported transcript-level clinical association of TMEM164 is reproducible across independent human glioblastoma cohorts and characterised its relationship with tumour status, necroptosis-related transcripts and recurrence.