Biomedicines
Joint Dynamic Trajectories of CEA and CA19-9 After Gastric Cancer Surgery: Prognostic Associations and a 12-Month Landmark Analysis
By Yicong Zeng, Tong Deng, Jiali Du and 7 others.
Abstract
Background
Static single-time-point assessment of carcinoembryonic antigen and carbohydrate antigen 19-9 cannot capture postoperative temporal patterns. We evaluated whether their joint longitudinal trajectories were associated with survival after curative gastrectomy while explicitly addressing the time-dependent bias created when trajectory groups are defined using measurements obtained after surgery.