Nitric oxide synthase activity and plasma cortisol during comprehensive therapy for non-q-wave myocardial infarction

Introduction. Non-Q-wave myocardial infarction is accompanied by changes in nitric oxide metabolism and the stress response. The biochemical effects of adding temgicoluril to standard treatment require clarification.

Aim. To assess changes in nitric oxide synthase isoform activity, nitrite, peroxynitrite and cortisol concentrations during standard therapy with or without temgicoluril.

Materials and methods. The prospective study included 40 patients (mean age 62.9±11.7 years, mean±standard deviation), divided into two groups of 20. Both groups received standard therapy and multidisciplinary rehabilitation. Group 2 additionally received temgicoluril, 500 mg three times daily for one month. Blood biochemical parameters were assessed before and after treatment and compared with those of 20 control participants.