Diagnostic Pathology
Malignancies in horseshoe kidneys: an updated review
By Simona Gurzu, Andrei-Cristian Fülöp and Tivadar Bara.
Abstract
Out of over 4000 available studies about horseshoe kidney (HSK), we selected 89 representative articles that emphasized the most common genetic lesions and tumors that can occur in these patients. Renal cell carcinomas, carcinomas of the urothelial tract, and Wilms tumor are the most common primary tumors reported to be associated with HSK. Besides a literature review, we present the 39th case of a neuroendocrine neoplasm (NEN) in an HSK, reported to date in Medline/Web of Science-indexed literature. From the 127 NENs of the kidneys reported till 2025, including our case, 39 associated HSK (30.71%). Based on an extensive literature review, a hypothesis regarding tumorigenesis inside of HSK is also formulated.
Keywords
- Renal cell carcinoma treatment
- Horseshoe kidney
- Carcinogenesis
- Renal cell carcinoma
- Wilms' tumor
- Kidney
- Neoplasm
- Open access
Source
Published in Diagnostic Pathology. The abstract is shown as published and remains the work of its authors; read the full article at the source.
Prognia lists this article for reference and education. It is not medical advice. Always read the original and follow current guidelines and local protocols before acting on it.