Abstract
Abstract New small molecule degrader DeDPP4 reduces dipeptidyl peptidase-4 protein levels and prolongs glucose lowering compared to alogliptin, supporting targeted protein degradation as a novel strategy for durable metabolic control. A full mechanistic understanding of how a system relying on intracellular degradation can act on a cell−surface protein will be instrumental in guiding the rational development of new degraders for this class of targets.
Keywords
- Peptidase Inhibition and Analysis
- Degradation (telecommunications)
- Intracellular
- Small molecule
- Protein degradation
- Cell
- Protein–protein interaction
- Cell culture
- Cell growth
- Open access
Source
Published in Journal of Medicinal Chemistry. The abstract is shown as published and remains the work of its authors; read the full article at the source.
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