Association Between Preoperative Dyslipidemia and the Prognosis of Patients With Endometrial Cancer: A Retrospective Cohort Study

ABSTRACT Endometrial cancer (EC) is closely related to metabolic disorders. We aimed to investigate whether preoperative dyslipidemia independently affects the prognosis of patients with EC. One hundred and ninety‐four women diagnosed with EC by pathology and who had undergone standardized surgical treatment at the Affiliated Hospital of Jining Medical College between June 2013 and December 2016 were enrolled. Participants were divided into high and low blood lipid groups based on the appropriate and abnormal stratification criteria in the Chinese Blood Lipid Management Guidelines (2023). Their clinical characteristics, preoperative blood lipids, and survival data were retrospectively collected and analyzed. A univariate Cox proportional hazards regression model showed that age at diagnosis, preoperative triglycerides (TG), preoperative high‐density lipoprotein cholesterol (HDL‐C), International Federation of Obstetrics and Gynecology (FIGO) stage, and histological type were risk factors affecting overall survival (OS) in patients with EC (p < 0.05). Furthermore, preoperative high TG levels (≥ 1.7 mmol/L) and low HDL‐C levels (< 1.0 mmol/L) had statistically significant negative impacts on the OS of patients with EC (both p < 0.05) in a multivariate Cox regression model. Moreover, the median survival time significantly differed based on TG and HDL‐C levels (low‐level vs high‐level: 91.2 months vs 81.6 months, p < 0.05; 72.8 months vs. 90.9 months, p < 0.05; respectively). In conclusion, higher TG or lower HDL‐C levels are associated with worse prognoses in patients with EC, which could serve as important biomarkers for evaluating the prognosis of patients with EC.