The Effect of Sublingual Atropine on Clozapine-Induced Sialorrhea in Patients with Schizophrenia: A Triple-Blind Randomized Clinical Trial

Abstract Background and Aim: Clozapine is the most effective treatment for patients with treatment-resistant schizophrenia; however, sialorrhea is a common and distressing side effect associated with its use. This study aimed to evaluate the effect of sublingual atropine on clozapine-induced sialorrhea in patients with schizophrenia.