Attenuated GlycoRNA-microglial transcriptional coupling in the dorsolateral prefrontal cortex of patients with major depressive disorder: an exploratory interaction-based in-silico analysis

Abstract Background: Glycosylated RNAs (GlycoRNAs) participate in immune recognition and intercellular communication, but their relationship with brain cell-type transcriptional signatures in major depressive disorder (MDD) remains unclear. We examined GlycoRNA-related transcriptional coupling with microglial and other cellular signatures in the dorsolateral prefrontal cortex (DLPFC).