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Guidelines
Neurology

ISRS 2020

International Stereotactic Radiosurgery Society

Stereotactic Radiosurgery for Intracranial Noncavernous Sinus Benign Meningioma: International Stereotactic Radiosurgery Society Systematic Review, Meta-Analysis and Practice Guideline

2020InternationalNeurosurgery

International

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Abstract
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Full guideline, as published849 KBOpen in a new tab Download

Abstract

Stereotactic radiosurgery (SRS) for benign intracranial meningiomas is an established treatment.

To summarize the literature and provide evidence-based practice guidelines on behalf of the International Stereotactic Radiosurgery Society (ISRS).

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Articles in English specific to SRS for benign intracranial meningioma, published from January 1964 to April 2018, were systematically reviewed. Three electronic databases, PubMed, EMBASE, and the Cochrane Central Register, were searched.

Out of the 2844 studies identified, 305 had a full text evaluation and 27 studies met the criteria to be included in this analysis. All but one were retrospective studies. The 10-yr local control (LC) rate ranged from 71% to 100%. The 10-yr progression-free-survival rate ranged from 55% to 97%. The prescription dose ranged typically between 12 and 15 Gy, delivered in a single fraction. Toxicity rate was generally low.

The current literature supporting SRS for benign intracranial meningioma lacks level I and II evidence. However, when summarizing the large number of level III studies, it is clear that SRS can be recommended as an effective evidence-based treatment option (recommendation level II) for grade 1 meningioma.

Source and rights

Published by Neurosurgery, 2020. The PDF is shown as published and remains the work of its authors and publisher; the original is at the source linked here. Rights holders can ask us to remove a file at info@prognia.nl.

pmc.ncbi.nlm.nih.gov/articles/PMC7566438/

Prognia summarises this guideline for reference and education. It is not medical advice. Always check the official guideline and current local protocols before acting on it.

At a glance

Organisation: International Stereotactic Radiosurgery Society
Published: 2020
Applies to: 🌐 International
Scope: International
Journal: Neurosurgery
DOI: 10.1093/neuros/nyaa169
PubMed: 32463867
PubMed Central: PMC7566438
Added to Prognia: 23 July 2026

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