Dextrose 5% in Plastic Container

Dextrose Injection is indicated as source of water and calories and may also be used as diluent for reconstitution of a powdered or liquid (up to 10 mL) drug product packaged in a vial with a 20 mm closure. Dextrose Injection is indicated as a source of calories and water and may also be used as diluent for reconstitution of a powdered or liquid (up to 10 mL) drug product packaged in a vial with a 20 mm closure. ( 1 )

The use of Dextrose Injection is contraindicated in patients with:

• Clinically significant hyperglycemia [see Warnings and Precautions (5.1) ].
• Known hypersensitivity to dextrose [see Warnings and Precautions (5.2) ]
• Clinically significant hyperglycemia. ( 4 )
• Known hypersensitivity to dextrose. ( 4 )

• Hyperglycemia or Hyperosmolar Hyperglycemic State: Monitor blood glucose and administer insulin as needed. ( 5.1 )
• Hypersensitivity Reactions : Monitor for signs and symptoms and discontinue infusion if reactions occur. ( 5.2 )
• Vein Damage and Thrombosis : Consider central vein when administering more than 5% dextrose or with an osmolarity of ≥ 900 mOsm/L or when there is peripheral vein irritation, phlebitis, and/or associated pain. ( 2.2 , 5.3 )
• Hyponatremia : Avoid in patients with or at risk for hyponatremia. If use cannot be avoided, monitor serum sodium concentrations ( 5.4 )
• Electrolyte Imbalance and Fluid Overload : Avoid in patients with or at risk for fluid and/or solute overloading. If use cannot be avoided, monitor daily fluid balance, electrolyte concentrations, and acid-base balance, as needed and especially during prolonged use ( 5.5 )
• Refeeding Syndrome : Monitor severely undernourished patients and slowly increase nutrient intake. ( 5.6 )

5.1