Dextrose 5% in Plastic Container

Dextrose Injection (5%) is indicated as a source of water and calories in adult and pediatric patients, and may also be used as a diluent for reconstitution of a powder or liquid drug product. Dextrose Injection (5%) is indicated as a source of water and calories in adult and pediatric patients, and may also be used as a diluent for reconstitution of a powder or liquid drug product. ( 1 )

Dextrose Injection (5%) is contraindicated in patients with: Clinically significant hyperglycemia [see Warnings and Precautions (5.2) ]. Known hypersensitivity to dextrose [see Warnings and Precautions (5.3) ]. Clinically significant hyperglycemia. ( 4 ) Known hypersensitivity to dextrose. ( 4 )

Neonatal Hypoglycemia: Closely monitor blood glucose concentrations to ensure adequate glycemic control. ( 5.1 ) Hyperglycemia and Hyperosmolar Hyperglycemic State: Use with caution in patients with known subclinical or overt diabetes mellitus. ( 5.2 ) Hypersensitivity Reactions: Monitor for signs and symptoms and discontinue infusion immediately if reaction occurs. ( 5.3 ) Phlebitis and Thrombosis: Remove catheter as soon as possible if thrombophlebitis develops.

( 2.1 , 5.4 ) Hyponatremia: Monitor serum sodium and chloride concentrations, fluid status, acid-base balance, and neurologic status. ( 5.5 ) Electrolyte Imbalance and Fluid Overload: Monitor changes in fluid balance, electrolyte concentrations, and acid-base balance during administration. ( 5.6 ) Refeeding Syndrome: Monitor laboratory parameters. ( 5.7 )

5.1Neonatal Hypoglycemia

Neonates, especially preterm neonates with low birth weight, are at increased risk of developing hypoglycemia. Closely monitor blood glucose concentration during treatment with Dextrose Injection (5%) to ensure adequate glycemic control in order to avoid potential long-term adverse effects.