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Frontiers in aging neuroscience
By Cerda-Pérez L, Gutiérrez-Rojas C, Retamal-Salazar V and 6 others.
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Dual-task training is proposed as a rehabilitative strategy to mitigate motor and cognitive impairments in patients with Parkinson's disease (PD). This systematic review and meta-analysis sought to consolidate existing information regarding the impact of dual-task therapies on health-related quality of life (HRQoL) and cognitive performance in middle-aged and older persons diagnosed with PD.
A systematic review of randomized controlled trials (RCTs) published to May 2026 was performed utilizing PubMed, EBSCOhost, Scopus, and Web of Science. The chosen studies adhered to the PICOS framework. The Methodological quality and certainty of evidence were assessed using the Cochrane Risk of Bias 2 tool and GRADE framework, respectively. The review protocol is recorded in PROSPERO under the number CRD420251159680.
Out of 3,037 identified records, 10 RCTs met the eligibility criteria and were included in the systematic review, of which 9 contributed data to the meta-analysis. The meta-analysis showed a statistically significant but modest effect on HRQoL measured with the Parkinson's Disease Questionnaire-39 (SMD = 0.35; 95% CI: 0.03-0.67; p = 0.03). No significant between-group effects were observed for TMT-A (MD = 0.99; 95% CI: -3.38 to 5.37; p = 0.66), TMT-B (SMD = 0.02; 95% CI: -0.24 to 0.29; p = 0.86), or MoCA (SMD = 0.19; 95% CI: -0.26 to 0.64; p = 0.41).
Dual-task interventions may produce a modest improvement in HRQoL in people with Parkinson's disease, whereas the current evidence does not demonstrate significant benefits for the cognitive outcomes assessed. These findings should be interpreted cautiously given the limited number of studies, methodological limitations, and clinical heterogeneity across interventions. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251159680, identifier CRD420251159680.
Published in Frontiers in aging neuroscience. The abstract is shown as published and remains the work of its authors; read the full article at the source.
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