Genomics of multidrug-resistant Klebsiella pneumoniae isolates from community hospitals in Pretoria, South Africa

Objectives

Multidrug-resistant (MDR) Klebsiella pneumoniae high-risk clones that produce carbapenemases and extended-spectrum β-lactamases (ESBLs) are a major public health threat, limiting treatment options. This study aimed to determine the prevalence, clonal diversity, and molecular characteristics of MDR carbapenemase-producing Klebsiella pneumoniae (CPKP) and ESBL-producing Klebsiella pneumoniae isolates from community hospitals in Pretoria, South Africa.