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Infection Prevention in Practice
By Mahoko Ikeda, Sachiko Hirose, Satomi Takei and 7 others.
Summary: Objectives: Carbapenem-resistant Enterobacterales (CRE) are a common source of healthcare-associated infections and nosocomial outbreaks. We examined a suspected nosocomial outbreak of carbapenem-resistant Klebsiella aerogenes in a surgical ward over a period of 11 months.
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We used whole-genome sequencing (WGS) to assess the genetic relatedness of eight detected isolates.
Molecular epidemiological analyses confirmed the outbreak as a pseudo-outbreak. During the period of assessment, the hospital infection control team implemented multiple interventions to promote stringent hand hygiene compliance, appropriate use of personal protective equipment, and adherence to best practices for wound care and body fluid management. Despite these measures, intermittent CRE isolation continued. Notably, WGS analyses revealed that all assessed isolates were genetically unique, with no evidence to indicate clonal relatedness.
The suspected nosocomial outbreak comprised sporadic, unrelated cases of CRE. Our findings in this study highlight the significance of molecular epidemiological tools in precisely evaluating suspected outbreaks of CRE and in directing the effective deployment of infection control resources.
Published in Infection Prevention in Practice. The abstract is shown as published and remains the work of its authors; read the full article at the source.
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