Multimodal profiling uncovers an aging-associated ETS1-MYO1B vascular niche responsive to ipragliflozin

Background

Tissue aging involves complex changes in vascular, immune, and stromal compartments that collectively reshape the local tissue ecosystem and may contribute to age-related diseases, including cancer, fibrotic diseases, and cardiovascular disease. However, it remains unclear whether reproducible, cell-specific vascular niche states emerge during aging and whether these states can be therapeutically targeted.