Design and validation of a bundle for assessing gonadal function in individuals with liver cirrhosis

Background

Liver cirrhosis (LC) constitutes the final stage of various chronic liver diseases and represents a serious public health problem. Its pathophysiology involves an inflammatory and fibrotic process that culminates in liver dysfunction and several systemic repercussions, including gonadal dysfunction with consequent hormonal alterations. Despite the clinical importance of this condition, there is a lack of studies that systematically address the assessment of gonadal function in men with LC, justifying the development of specific instruments for this purpose.