Association of Genetic Variants of ABCC8 Gene With Type 2 Diabetes Mellitus in the Mongolian Population

Introduction

Type 2 diabetes constitutes 90 percent of all diabetes cases, and some polymorphism in the ABCC8 gene, which encodes the ATP-sensitive potassium channel Sur1 protein involved in pancreatic beta cell insulin release, are associated with Type 2 diabetes. Sulfonylurea is used to treat diabetes caused by this metabolic disorder. Recent studies indicate that the rs1799854 and rs1801261 polymorphisms of the ABCC8 gene may be associated with the development of Type 2 diabetes.