Quantitative phage-host interaction profiling supports the design of a broadly active phage cocktail against multidrug-resistant Enterococcus faecalis from poultry

Introduction

Enterococcus faecalis is an opportunistic pathogen of One Health relevance and an important reservoir of antimicrobial resistance in poultry production systems. In this study, we generated a large-scale quantitative phage-host interaction dataset to support the rational design of phage cocktails targeting multidrug-resistant poultry-associated E. faecalis.